Molecular Systems Engineering Lab

(Genomic Energy of Bioresources)

Department of bioinformatics

Books and Chapters


  • Prathiviraj R, Sheela Berchmans and Chellapandi P (2019) Analysis of modularity in proteome-wide protein interaction networks of Methanothermobacter thermautotrophicus strain ΔH across metal-loving bacteria. Journal of Proteins and Proteomics (Accepted)
  • Bharathi M, Chellapandi P (2019) Reconstruction and analysis of transcriptome regulatory network of Methanobrevibacter ruminantium M1. BMC Systems Biology (Accepted)
  • Prathiviraj R, Chellapandi P (2019) Evolutionary genetic analysis of unassigned peptidase clan-associated microbial virulence and pathogenesis. Infection Genetics and Evolution (Accepted)
  • Bharathi M, Chellapandi P (2019) Comparative analysis of differential proteome-wide protein-protein interaction network of Methanobrevibacter ruminantium M1. BMC Genomics (Accepted)
  • Sangavai C, Chellapandi P, Bharathi M, Shilpkar P (2019) Kinetic modeling of stickland reactions-coupled methanogenesis for a methanogenic culture. AMB Express (Accepted)
  • Chellapandi P (2019) Computational evaluation of designed phosphatase from a conserved sequence scratches for diverse substrate specificity. International Journal of Bioautomation (Accepted) (Impact factor: 0.548)
  • Chellapandi P, Prathiviraj R, Prisilla A (2019) Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints. Journal of Computer-Aided Molecular Design 33:419-436 (Impact factor: 2.356)
  • Prisilla A, Roja A, Chellapandi P (2019) A human-food web-animal Interface on the prevalence of food-borne pathogens (Clostridia and Enterococcus) in mixed veterinary farms. Food Science and Biotechnology 10.1007/s10068-019-00595-8 (Impact factor: 0.706)
  • Prisilla A, Chellapandi P (2019) Cloning and expression of immunogenic Clostridium botulinum C2I mutant proteins designed from its evolutionary imprints. Comparative Immunology, Microbiology and Infectious Diseases. (Impact factor: 2.149)


  • Prathiviraj R, Chellapandi P (2018) Functional annotation of operome from Methanothermobacter thermautotrophicus ΔH: An insight to metabolic gap filling. International Journal of Biological Macromolecules 123:350-362. (Impact factor: 3.929)
  • Chellapandi P and Prisilla A (2018) PCR-based molecular diagnosis of botulism outbreaks in aquatic birds. Annals of Microbiology 68: 835-849. (Impact factor: 1.607)
  • Chellapandi P, Prathiviraj R, Prisilla A (2018) Molecular evolution and functional divergence of IspD homologs in malarial parasites. Infection Genetics and Evolution 65:340-349. (Impact factor: 2.737)
  • Chellapandi P, Prathiviraj R, Sangavai C, Bharathi M (2018) Methanobacterium formicicum as a target rumen methanogen for the development of new methane mitigation interventions. Veterinary and Animal Science 6: 86-94.
  • Chellapandi P and Prisilla A (2018) Clostridium botulinum type A-virulome-gut interactions: A systems biology insight. Human Microbiome Journal 7: 15-22. (Impact factor: 0.133)
  • Razia M, Karthik Raja R, Padmanaban K, Chellapandi P, Sivaramakrishnan S (2018) Phylogeographic analysis of entomopathogenic nematophilic symbiotic bacteria using 16s rDNA gene sequencing. Munis Entomology & Zoology Journal 13: 604-6015.


  • Sangavai C and Chellapandi P (2017) Amino acid catabolism-directed biofuel production in Clostridium sticklandii: An insight into model-driven systems engineering. Biotechnology Reports 16: 32-43. (Impact factor: 1.621)
  • Prisilla A, Prathiviraj R, Chellapandi P (2017) Molecular evolutionary constraints that determine the avirulence state of Clostridium botulinum C2 toxin. Journal of Molecular Evolution 86 174-186. (Impact factor: 1.957)
  • Bharathi M and Chellapandi P (2017) Phylogenomic proximity and metabolic discrepancy of Methanossarcina mazei Go1 across methanosarcinal genomes. BioSystems 155:20-28. (Impact factor: 1.609)
  • Chellapandi P and Prisilla A (2017) Structure, function and evolution of Clostridium botulinum C2 and C3 toxins: Insight to poultry and veterinary vaccines. Current Proteins and Peptide Sciences 18(5): 412-424. (Impact factor: 3.105)
  • Chellapandi P, Mohamed Khaja Hussain M, Prathiviraj R (2017) CPSIR-CM: a database for structural properties of predicted proteins in cyanobacterial C1 metabolism. Algal Research 22: 135-139. (Impact factor: 5.014)
  • Bharathi M and Chellapandi P (2017) Intergenomic evolution and metabolic cross-talk between rumen and thermophilic autotrophic methanogenic archaea. Molecular Phylogenetics and Evolution 107: 293–304. (Impact factor: 4.412)
  • Chellapandi P, Bharathi M, Prathiviraj R, Sasikala R, Vikraman R (2017) Genome-scale metabolic model as a virtual platform to reveal the environmental contribution of methanogens. Current Biotechnology 7: DOI: 10.2174/2211550105666160901125353


  • Prisilla A, Prathiviraj R, Sasikala R, Chellapandi P (2016) Structural constraints-based evaluation of immunogenic avirulent toxins from Clostridium botulinum C2 and C3 toxins as subunit vaccines. Infection, Genetics and Evolution 44: 17-27. (Impact factor: 2.737)


  • Chellapandi P and Ranjani J (2015) Knowledge-based discovery for designing CRISPR-CAS systems against invading mobilomes in thermophiles. Systems and Synthetic Biology 9: 97-106. (Impact factor: 1.0)
  • Prathiviraj R, Prisilla A, Chellapandi P (2015) Structure-function discrepancy in Clostridium botulinum C3 toxin for its rational prioritization as a subunit vaccine. Journal of Biomolecular Structure and Dynamics 34:1317-1329. (Impact factor: 3.107)
  • Chellapandi P (2015) In silico analysis of heavy metal assimilation behaviors in the genome of Methanosarcina barkeri str. Fusaro. Current Bioinformatics 10(1): 59-68. (Impact factor: 0.627)
  • Padmanaban K, Karthik Raja R, Razia M, Chellapandi P, Sivaramakrishnan S (2015) Genetic diversity of entomopathogenic nematodes in undisrupted ecosystem revealed with PCR-RAPD markers. International Journal of Nematology 24(2): 1-8.
  • Acharya KP, Shilpkar P, Shah MC, Chellapandi P (2015) Biodegradation of the monocrotophos by Bacillus substilis KPA-1, isolated from agriculture soils in India. Applied Biochemistry and Biotechnology 175(4): 1789-1804. (Impact factor: 1.797)


  • Chellapandi P (2014) Structural evaluation of snake venom metalloproteinases and their therapeutic uses. Mini Review in Organic Chemistry 11(1): 28-44. (Impact factor: 1.075)
  • Chellapandi P (2014) Structural-functional integrity of hypothetical proteins identical to ADP-ribosylation Superfamily upon point mutations. Protein and Peptide Letters 21(8): 722-735. (Impact factor: 1.052)


  • Chellapandi P, Sakthi Shree S, Bharathi M (2013) Phylogenetic approach for inferring the origin and functional evolution of bacterial ADP-ribosylation superfamily. Protein and Peptide Letters 20(9): 1054-1065. (Impact factor: 1.052)
  • Chellapandi P (2013) Computational studies on enzyme-substrate complexes of methanogenesis for revealing their substrate binding affinities to direct the reverse reactions. Protein and Peptide Letters 20(3): 265-278. (Impact factor: 1.052)


  • Chellapandi P and Uma L (2012) Evaluation of methanogenic activity of biogas plant slurry on ossein factory wastes. Journal of Environmental Science and Engineering 54 (1): 10-13. (Impact factor: 0.337)
  • Karthik Raja R, Padmanaban K, Razia M, Chellapandi P, Sivaramakrishnan (2012) Evaluating Heavy metal stress responses of nematodes in the agro-ecosystem of Tamil Nadu in South India. Journal of Advances in Developmental Research 3(1): 49-51.
  • Razia M, Rajkuberan C, Karthik Raja R, Padmanaban K, Chellapandi P, Sivaramakrishnan S (2012) Agriculture practices diminished the entomophilic nematode diversity in Karur District of Tamil Nadu, India. Journal of Advances in Developmental Research 3(1): 45-48.
  • Karthik Raja R, Razia M, Padmanaban K, Chellapandi P, Sivaramakrishnan S (2012) Survey and assessment of soil nematodes in Tsunami impacted agricultural areas of South India. Journal of Advances in Developmental Research 3(1): 40-44.
  • Chellapandi P and Uma L (2012) Co-digestion of ossein factory waste for methane production in batch. Elixer Biotechnology 42: 6383-6385.
  • Chellapandi P and Balachandramohan J (2012) Cobalt and nickel-containing enzyme constructs from the sequences of methanogens. Biopolymers and Cell 28(1): 68-74. (Impact factor: 0.417)


  • Chellapandi P (2011) Current scenario of computer-aided metalloenzymes designing. Biopolymers and Cell 27(6):432-435. (Impact factor: 0.417)
  • Chellapandi P (2011) Molecular evolution of methanogens based on their metabolic facets. Frontiers in Biology 6(6):490-503. (Impact factor: 0.986)
  • Chellapandi P (2011) In silico description of cobalt and tungsten assimilation systems in the genomes of methanogens. Systems and Synthetic Biology 5: 105-114. (Impact factor: 1.0)
  • Chellapandi P and Sivaramakrishnan S (2011) Current evolutionary genomic perspective of methanogens. Advanced Biotech 11(4): 29-35.
  • Sundaramoorthy M, Saravanan TS, Shivashanmugam P and Chellapandi P (2011). Identification and sequencing of a cDNA clone encoding cathelicidin-like antimicrobial peptide from chicken heart tissues. Electronic Journal of Biology 7(2): 26-31. (Impact factor: 0.75)
  • Razia M, Padmanaban K, Karthick Raja R, Chellapandi P, Sivaramakrishnan S (2011) 16S rDNA-based phylogeny of non-symbiotic bacteria of Entorno-pathogenic nematodes from infected insect cadavers. Genomics, Proteomics and Bioinformatics 9(3): 104-112. (Impact factor: 6.615)
  • Chellapandi P and Balachandramohan J (2011) Molecular evolution-directed approach for designing archaeal formyltetrahydrofolate ligase. Turkish Journal of Biochemistry 36(2): 122-135. (Impact factor: 0.356)
  • Chellapandi P and Balachandramohan J (2011) Molecular evolution-directed approach for designing of β-methylaspartate mutase from the sequences of Haloarchaea. International Journal of Chemical Modeling 3(3): 143-154.
  • Razia M, Padmanaban R, Karthik Raja R, Chellapandi P, Sivaramakrishnan S (2011) Monitoring entomopathogenic nematodes as ecological indicators in the cultivated lands of Karur District, Tamil Nadu: A survey report. Electronic Journal of Biology 7(1): 16-19. (Impact factor: 0.75)
  • Razia M, Padmanaban K, Karthick Raja R, Chellapandi P, Sivaramakrishnan S (2011) PCR-RFLP pattern analysis of entomopathogenic nematodes isolated from agro-ecosystem for implicating their genetic diversity. Munis Entomology and Zoology 6(1): 404-411
  • Chellapandi P and Ranjani J (2011) Molecular machinery of CRISPR-CAS system – RNA mediated defense pathway in Prokaryotes. Asian Journal of Biotechnology 3(4): 329-336. (Impact factor: 0.60)
  • Chellapandi P (2011) A molecular conception for protein engineering algorithms. Advanced Biotech 10(7): 41-46.
  • Pazhanivel G, Chandrasekaran P, Prabha D.S, Bhuvaneswari B, Malliga P, Chellapandi P (2011) Effect of coir pith based cyanobacterial biofertilizer for improving fatty acid contents in Arachis hypogaea. L (Groundnut) oilseeds. Journal of Advances in Developmental Research 2(1): 38-41.


  • Chellapandi P and Kalaimathy S (2010) Molecular aspects of beta-galactosidase production system in Aspergillus genomes. Journal of Advances in Developmental Research 1(1): 81-89.
  • Chellapandi P and Dhivya C (2010) Overview of microbial metabolomics: A special insight to cyanobacterial methylotrophy. Journal of Advances in Developmental Research 1(1): 59-73
  • Chellapandi P, Sivaramakrishnan S, Viswanathan MB (2010) Systems biotechnology: An emerging trend in metabolic engineering of industrial microorganisms. Journal of Computer Science and Systems Biology 3(2): 43-49. (Impact factor: 0.297)
  • Razia M, Raja KR, Padmanaban K, Sivaramakrishnan S, Chellapandi P (2010) A phylogenetic approach for assigning function of hypothetical proteins in Photorhabdus luminescens subsp. laumondii TT01 genome. Journal of Computer Science and Systems Biology 3(1): 21-29. (Impact factor: 0.297)
  • Chellapandi P (2010) Pharmacological perspectives of snake venoms from Viperidae family. Internet Journal of Pharmacology 8(2). DOI: 10.5580/e36 (Impact factor: 1.36)
  • Chellapandi P (2010) Production and preliminary characterization of alkaline protease from Aspergillus flavus and Aspergillus terreus. E-Journal of Chemistry 7(2): 479-482. (Impact factor: 1.726)
  • Chellapandi P, Prabaharan D, Uma L (2010) Evaluation of methanogenic activity of biogas plant slurry for monitoring codigestion of ossein factory wastes and cyanobacterial biomass. Applied Biochemistry and Biotechnology 162(2): 524-535. (Impact factor: 1.797)


  • Chellapandi P and Jani AA (2009) Enhanced endoglucanase production by soils isolates of Fusarium sp. and Aspergillus sp. through submerged fermentation process. Turkish Journal of Biochemistry 34(4): 209-214. (Impact factor: 0.356)
  • Vedhagiri K, Natarajaseenivasan K, Chellapandi P, Prabhakaran SG, Selvin J, Sharma S, Vijayachari P (2009) Evolutionary implication of outer membrane lipoprotein-encoding genes ompL1, ompL32 and lipL41 of pathogenic Leptospira species. Genomics, Proteomics and Bioinformatics 7(3): 96-106. (Impact factor: 6.615)
  • Chellapandi P, Karthigeyan C, Sivaramakrishnan S (2009) Evolutionary implication of protein secondary structure among archaea and bacteria. Internet Journal of Genomics and Proteomics 4(2). DOI: 10.5580/1208 (Impact factor: 0.216)
  • Patel CN and Chellapandi P (2009). Anaerobic digestion of cotton seed cake using developed mixed consortia. Electronic Journal of Environment, Agriculture and Food Chemistry 8(5): 333-344. (Impact factor: 0.343)


  • Chellapandi P, Prabaharan D, Uma L (2008) A preliminary study on co-digestion of ossein factory waste for methane production. EurAsian Journal of Biosciences 2: 110-114. (Impact factor: 0.326)
  • Chellapandi P (2008) Rural Biotechnology: Alternate and ultimate approaches for rural development in India. International Journal of Rural Studies 15(2): 31-35.
  • Vijaya D, Padmadevi SN, Vasandha S, Meerabhai RS, Chellapandi P (2008) Effect of vermicomposted coirpith on the growth of Andrographis paniculata. Journal of Organic Systems 3(2): 51-56.
  • Sangavai C and Chellapandi P (2008). In vitro propagation of a tuberose plant (Polianthes tubarosa, L). Electronic Journal of Biology 4(3): 98-101. (Impact factor: 0.75)
  • Chellapandi P and Rabari BN (2008) Solid-state cultivation of Aspergillus niger NCIM 548 for glucoamylase production on groundnut shell. Internet Journal of Microbiology 5(1). DOI: 10.5580/26c1 (Impact factor: 0.24)
  • Chellapandi P and Jebakumar SRD (2008) Purification and antibacterial activity of Indian cobra and viper venoms. Electronic Journal of Biology 4(1): 11-16. (Impact factor: 0.75)
  • Chellapandi P and Jani HM (2008) Production of endoglucanase by the native strains of Streptomyces isolates in submerged fermentation. Brazilian Journal of Microbiology 39: 122-127. (Impact factor: 1.039)
  • Amin SB and Chellapandi P (2008) Production of extra cellular proteinase by Aspergillus foetidus NCIM 505 on milk powder and soya bean meal based media. Research Journal of Biotechnology 3(1): 33-38. (Impact factor: 0.233)


  • Karthigeyan C, Sivaramakrishnan S, Chellapandi P (2007) Phylogenomic analysis of archaeal domain. Bioinformatics Trends2(1): 37-55.
  • Chellapandi P, Karthigeyan C, Sivaramakrishnan S (2007) Phylogenomic analysis of archaeal domain-An overview. Research and Reviews Journal of Bioscience 1(4-5): 160-168.
  • Chellapandi P, Suman LS, Sivaramakrishnan S (2007) Biomethanation of fungal predigested caster seed cake in acclimatized seed. Biotechnology, An Indian Journal 1(3): 19-24. (Impact factor: 0.187)